CRP and schizophrenia: On the other hand, high triglycerides and C-reactive protein levels at baseline have been linked to unfavorable clinical outcomes and a decreased rate of treatment response at one-year follow-up (60), and a second study identified an interaction between lipids and inflammation as a predictor of worse negative symptom severity in patients with schizophrenia, which suggests a mediating role of inflammation in the association between hypertriglyceridemia and readmission.