To identify genes whose expression changed significantly upon inhibition of PIKFYVE in melanoma A375 cells, but not in human foreskin fibroblasts HFF1 cells, A375 and HFF1 cells were cultured in either vehicle, or in 0.05 μm WX8 to selectively inhibit PIKFYVE, or 1 μm WX8 to inhibit both PIKFYVE and PIP4K2C. Here, PIKFYVE is linked to melanoma.