Unlike thapsigargin, tunicamycin, and nonsteroidal anti‐inflammatory drugs that induce IL24 ER‐stress indiscriminately, PIKFYVE inhibitors selectively trigger cell death in melanoma cells The nonsteroidal anti‐inflammatory drug sulindac sulfide is a reversible inhibitor of the ER Ca2+ ATPase that triggers IL24 ER‐stress via the same mechanism as thapsigargin [76, 77]. Here, PIKFYVE is linked to melanoma.