As with thapsigargin, WX8 induced PERK‐dependent phosphorylation of EIF2A protein and upregulation of ATF4 and DDIT3 proteins in melanoma A375 cells (Fig. 3A) accompanied by translocation of transcription factors ATF4 and CEBPb to the nucleus (Fig. 3B). This evidence concerns the gene EIF2AK3 and melanoma.