Therefore, the present study aimed to further evaluate the pathogenic role of HMGB1 in psoriasis by exploring the possible regulatory effect of HMGB1 on Th17 cell differentiation, which revealed that HMGB1 can promote Th17 cell differentiation and IL‐17A production in a dose‐dependent manner in the PBMCs from psoriasis patients and supplemented data for HMGB1‐based therapeutic strategies. This evidence concerns the gene HMGB1 and psoriasis.