HMGB1 and pulpitis: Previous research about the regulatory effect exerted on macrophages from dental pulp tissue specimens of pulpitis and healthy pulps by HMGB1 stimulation has shown that compared with HMGB1‐unstimulated cells, the IL‐17 levels in culture supernatants were significantly increased in the case of HMGB1 stimulation, especially in pulpitis samples,45 which further indicates that the promotional effect of HMGB1 on Th17 cell differentiation is an important immune regulatory pathway in pathological conditions.