When we examined the contribution of each variable, we found that the dose of the APOE ε4 allele significantly affected the conversion to AD (HR = 1.604, 95% CI = 1.153–2.230, and p value = 0.005 in the PRS.noAPOE; HR = 1.560, 95% CI = 1.102–2.209, and p value = 0.012 in the PRS.adjLD, Wald test; Table 5a), suggesting that this difference in conversion between the two PRS groups was influenced by the APOE ε4 allele dose. Here, APOE is linked to Alzheimer disease.