However, one of the most important characteristics of GIST cells in both treatment-naive or TKIs-resistant cells is that its high dependency on KIT signal that necessitate the recapitulation of the underlying biology or mechanism of KIT mutations and expression, with the purpose of developing novel drugs, alone or combined with current KIT-TKIs, to prevent or reverse resistance via the complete elimination of KIT oncogenesis. Here, KIT is linked to gastrointestinal stromal tumor.