KIT and gastrointestinal stromal tumor: And intriguingly, use of an aptamer-based method for KIT expression targeted detection of GIST was successfully executed in vitro and in vivo, and intracellular delivery of TKIs to signaling terrace via anti-KIT DNA aptamer or modified RNA aptamers to inhibit the activity of KIT kinase, heralding a novel avenue in GIST treatment [196, 197].