It is reported that the super-enhancer was shared by Anoctamin 1(ANO1), which encodes the GIST clinical biomarker also known as DOG-1 (‘Discovered on GIST-1’) and FGF3/4, which reside in a ~ 250 kb TAD flanked by boundaries that contain CTCF binding sites, and the adjacent TAD on the 11q side contains a large cluster of super enhancer (SE), was recently observed in SDH-defcient GIST. The gene discussed is FGF3; the disease is gastrointestinal stromal tumor.