In GIST, BRD4 binds the acetylated lysine in histones or TF in enhancer or recruited pTEFb to initiate NFκB-dependent acetylated histones, promoting the transcription of c-KIT and C–C motif chemokine ligand 2 (CCL2), which is a chemokine recruiting macrophages to tumor functions as an immunosuppressor [113]. This evidence concerns the gene BRD4 and gastrointestinal stromal tumor.