METTL3 and gastrointestinal stromal tumor: The levels of methyltransferase-like 3 (METTL3) is elevated and confer to Imatinib resistance in GIST patients, because METTL3 mediate the m6A modification on the 5’UTR of the multidrug transporter MRP1 mRNA, which facilitating MRP1 mRNA translation [108].