KIT and gastrointestinal stromal tumor: In KIT-mutated GIST, chromosomes are frequently lost at 1q, 13q, 14q, 22q, etc., involving Protein phosphatase 1A (PPM1A), kinesin family member 1B (KIF1B) and neurofibromin 2 (NF2) gene, but this loss does not occur in WT GIST, which show the alternative epigenetic alterations [28].