Similarly, HAND1 is involved in the transcriptional amplification of the KIT oncogene via its influence on the expression or protein interactions of the core TF network of KIT [35], including ETV1, HIC1 (hypermethylated in cancer 1), FOXF1 and other GIST-correlated protein, and G protein-coupled receptor 20(GPR20) [81]. Here, HAND1 is linked to gastrointestinal stromal tumor.