CD4 and neoplasm: We performed non-negative matrix [35] factorization based on the proportions of these cell types within the tumor microenvironment (TME) for each sample, categorizing them into six groups: Epithelialhi TME, Myeloidhi TME, B cellhi TME, CD8+ T cellhi TME, CD4+ T cellhi TME, and Stromalhi TME) (Fig. 1C).