Apolipoprotein C-III (Apo CIII), angiopoietin protein-like 3 (ANGPTL3), proprotein convertase subtilisin/kexin type 9 (PCSK9) modify circulating lipid levels (Low-density Lipoprotein or LDL, and high-density lipoproteins or HDL levels) and thus modulate lipid supplies to extra-hepatic tissues, including cancer cells. This evidence concerns the gene PCSK9 and cancer.