Moreover, circMAP2K2, which is upregulated in GC, regulates the poly(rC)-binding protein 1/glutathione peroxidase 1 axis through proteasome-mediated degradation, and activates the AKT/glycogen synthase kinase-3β/epithelial-to-mesenchymal transition signaling pathway to enhance GC cell proliferation and metastasis [35]. This evidence concerns the gene AKT1 and gastric cancer.