AXIN1-295aa activates Wnt/β-catenin signaling by competing with axis inhibition protein 1 and binding to adenomatous polyposis coli, eventually promoting the proliferation and metastasis of GC cells by elevating the expression of Wnt-response genes (Cyclin D1, c-Myc, c-Jun, etc.)[42]. Here, AXIN1 is linked to gastric cancer.