Therefore, this study aimed to determine whether exosomal ADAM17 can disrupt homologous proteins of the E-cadherin family [28], such as VE-cadherin in vascular endothelial cells; additionally, we investigated the role of ADAM17 in mediating endothelial barrier function during CRC hematogenous metastasis. This evidence concerns the gene ADAM17 and colorectal carcinoma.