Compared with that in the Nor-HCT116 exosome treatment group, EMT-HCT116 exosomes significantly reduced VE-cadherin expression at the invasive front of CRC tumors (Fig. 4b, c); this was accompanied by an increase in CTCs in mouse blood and an increase in the proportion of mice with both lung and liver metastasis (Fig. 4c). The gene discussed is CDH5; the disease is colorectal carcinoma.