ADAM17 and neoplasm: Based on the exosomal ADAM17 levels in the serum of patients with tumors, exosomal ADAM17 expression was negatively correlated with VE-cadherin, p120, and E-cadherin levels at the tumor invasive front and positively correlated with the expression of tumor blood metastatic protein vimentin (Fig. 1d-e and S2B).