Compared with those in the low-stable, participants with a moderate-stable and high-stable trajectories of UA were more likely to be men, to be more current alcohol consumers, to be more current smokers, and to have a higher BMI, SBP, DBP, FBG, TG, CRP, UA at the first visit and baseline, while they had higher prevalence of hypertension, and taking antihypertensive drugs, and lipid-lowering drugs was more prevalent (all P < 0.05). This evidence concerns the gene CRP and Hypertension.