Aside from their structural functions, these genes are also widely known as axon markers (MAPT, TRIM46; [63, 64], non-canonical WNT pathway output genes (CAMK2A, DAAM1, [62, 65] and as candidate genes for neurodevelopmental disorders (CAMK2A, ANK2, DCX, SCN2A, [66–69], highlighting their importance for cell functionality. This evidence concerns the gene TRIM46 and neurodevelopmental disorder.