The Alere Determine TB LAM antigen assay (AlereLAM) is currently the only product recommended by the WHO for the detection of LAM in urine samples [2], but it only has moderate sensitivity (40–60%) in HIV co-infected patients with low CD4 counts, and low sensitivity (10–20%) in active TB (ATB) only patients [4, 5]. Here, CD4 is linked to tuberculosis.