LTF and Acute otitis media: Finally, 52 infants were given either regular cow milk based formula or formula with added bovine lactoferrin for one year in a US trial; while the lactoferrin supplemented formula was associated with a significant (p<0.05) reduction in the average number of lower respiratory tract infections (LRTI) per infant-year, similar associations were not observed for URTI or acute otitis media (AOM) and no differences in disease duration were found [46].