Hence, our hypothesis posits that the regulation of Nfe2l2 may have a modulatory effect on Ptprm, Nrxn1, Col1a2, and electron transport chain, rendering Nfe2l2, Ptprm, Nrxn1, and Col1a2 potential targets for drug intervention in the treatment of SNHL. Here, NFE2L2 is linked to sensorineural hearing loss disorder.