OPA1 and chronic obstructive pulmonary disease: In line with these results, we did not observe pronounced alterations in the regulation of mitochondrial content, metabolism or dynamics in undifferentiated or differentiated PBEC cultures from COPD-patients compared to non-COPD patients, except a downregulation of OPA1 expression (mitochondrial fission) in differentiated PBEC from COPD patients (Tables S4 and S5; Figs. S2 and S3).