RPS6KB1 and infection: We therefore challenged young fat bodies ex vivo with Ecc15. Although Ecc15 infection led to a clear induction in the number of Relish-positive nuclei under basal conditions, knockdown of S6K failed to repress this induction (Extended Data Fig. 8a), suggesting that the effect of S6K on the IMD pathway is indirect and dependent on age-dependent changes in fat bodies.