These included five standard of care therapies, 5-fluorouracil, oxaliplatin, leucovorin, SN-38 (the active metabolite of irinotecan), and regorafenib, two pharmacological inhibitors of arginine methyltransferases 4 (PRMT4) and 5 (PRMT5), TP-064 and pemrametostat respectively, and three epigenetic therapies currently employed in clinical trials against CRC, decitabine (NCT01193517), entinostat (NCT01105377) and vorinostat (NCT00942266). This evidence concerns the gene PRMT5 and colorectal carcinoma.