These included five standard of care therapies, 5-fluorouracil, oxaliplatin, leucovorin, SN-38 (the active metabolite of irinotecan), and regorafenib, two pharmacological inhibitors of arginine methyltransferases 4 (PRMT4) and 5 (PRMT5), TP-064 and pemrametostat respectively, and three epigenetic therapies currently employed in clinical trials against CRC, decitabine (NCT01193517), entinostat (NCT01105377) and vorinostat (NCT00942266). Here, CARM1 is linked to colorectal carcinoma.