Interrogations into components of 10 canonical oncogenic pathways as identified previously, revealed that genes related to signalling pathways frequently associated with CRC progression, including the Wnt, Hippo, Ras and p53 signalling pathways, were mutated in at least 10 of the 12 matched metCRC samples (83.3%) (Fig. 3b and Supplementary Table 2)43. The gene discussed is TP53; the disease is colorectal carcinoma.