NLGN2 and cancer: In these cells, as well as in duodenal tuft cells (Gerbe et al, 2009), NLGN2 was coexpressed with doublecortin-like kinase 1 (DCLK1) (Fig. EV2C), an interactor of NLGN2 (Kang et al, 2014) and a stemness marker in several cancers, including pancreatic preinvasive lesions, and in the gastrointestinal tract (Bailey et al, 2014; Westphalen et al, 2014).