CAD and acute lymphoblastic leukemia: In line, here we identified 14 (9%) of the ALL patients without SMN with unfavorable CPG variants, and in 6 of these cases (4% of the control patients) an underlying CPS may be suspected, either because the variant was determined to be homozygous (i.e. NBN) or due to an autosomal dominant inheritance mode of the associated phenotype (see Table 1 for details).