IDH2 and breast cancer: Thus we mainly focused on the expression status of IDH2 in BRCA, and we used the single-cell sequencing data of breast cancer from the TCGA (The Cancer Genome Atlas) public database for clustering analysis of differentially expressed genes (DEGs) between different molecular subtypes of BRCA and found that IDH2 was significantly highly expressed in TNBC through GO functional enrichment analysis and ferroptosis pathway aggregation analysis, and the high expression status of IDH2 showed a significant positive correlation with poor prognosis of BRCA (Fig. 1B–H).