IDH2 and neoplasm: After drug treatment, the NC group showed a significant increase in tumor shrinkage, while the shRNA-IDH2 group showed no significant change (NC + erastin vs. shRNA-IDH2 + erastin = 83.63 ± 2.616 vs. 12.55 ± 2.116, p < 0.0001, Fig. 5B–D).