IDH2 and neoplasm: In summary, by analyzing the gene expression profiles of single-cell sequencing of breast cancer tumors in large passages, as well as screening genomics for functional enrichment and genes related to ferroptosis bioprocesses, and through further validation at the in vitro cellular level and establishment of in vivo mouse tumor models, we have identified that TNBC abnormally high expression of the IDH2 gene affected the degree of ferroptosis of TNBC cells by regulating the expression level of the GPX4 gene, which in turn modulates the TNBC malignant biosignature.