KRT18 and infection: Despite the number of animals included in each experimental group was low due to difficulties of obtaining advanced-age animals (particularly in the mice group), we can conclude that a prime-boost administration of adjuvanted S-29 in our advanced geriatric models ameliorated some of the clinical signs in K18-hACE2-mice and GSH, and improved survival in mice, but did not prevent infection, with minimal effect on the viral load and some histopathological findings.