LAMA2 and limb-girdle muscular dystrophy: For instance, patients carrying loss-of-function pathogenic variants in LAMA2 encoding for the extracellular protein Laminin alpha 2, present with the most severe form of CMD (MDC1A, MIM607855), whereas missense pathogenic variants lead to a milder, later-onset LGMD (LGMDR23, MIM618138)2.