In addition, podocyte apoptosis in diabetic nephropathy has been found to be closely associated with the regulation of various miRNAs.244 Disturbed lipid levels in circulation enhance FOXO1 activity and induce insulin resistance by modifying the abundance of H3K36me2 and H3K27me3 on the promoter region of FOXO1 in human urine-derived podocyte-like epithelial cells (HUPECs). This evidence concerns the gene FOXO1 and Insulin resistance.