INS and Insulin resistance: Obese individuals undergoing metabolic surgery appear to have epigenetic and metabolic changes in skeletal muscle that accompany the process of improved insulin sensitivity.309 You et al. identified DNMT3a as essential for mediating insulin resistance of both murine and human adipocytes.310 Knockout of the DNMT3a gene in mice adipose tissue avoids diet-associated insulin resistance yet does not result in altered adiposity.