GSK3B and cancer: For instance, in breast cancer cell line MDA-MB-231, exposure to a hyperglycemic environment triggers dephosphorylation and activation of GSK-3β, which is vital in mediating insulin-dependent glycogen synthesis.411 Upregulation of GSK-3β enhances phosphorylated imprinting of histone H3, which mediates the upregulation of metastatic genes along with promoting epithelial-mesenchymal transition (EMT) and cancer cell proliferation.