Recent studies have suggested that neutrophil extracellular traps may also contribute to periodontal bone destruction by activating TH17 cells.39,40 In this study, we demonstrated that neutrophils may stimulate osteogenic RANKL expression through cytokine secretion, providing novel insights into the role of neutrophils in the pathogenesis of periodontitis. The gene discussed is TNFSF11; the disease is periodontitis.