In bone destruction associated with RA, the distal enhancer E3 region regulates RANKL expression in synovial fibroblasts.59 The findings of the current study indicate that the STAT3-binding RL-D4 region may be involved in OSM-induced RANKL expression in osteogenic cells and contribute to bone damage in periodontitis. This evidence concerns the gene TNFSF11 and periodontitis.