Moreover, the lung cancer-specific OS rate significantly increased in patients with TBX2 subfamily high expression group than that in low expression group (TBX2 logrank P = 0.0023, TBX3 logrank P = 1.9e-5, TBX4 logrank P = 0.027, TBX5 logrank P = 2.2e−10). Here, TBX4 is linked to lung cancer.