ALB and chronic kidney disease: Among the 75 metabolites associated with incident CVD, 22 remained nominally significant after further adjusting for CKD and severely increased albuminuria (ESM Fig. 3, ESM Table 5), including concentrations of very small VLDL and small HDL and their lipid components, triglycerides in intermediate-density lipoprotein (IDL), LDL and larger HDL, leucine and albumin.