Although endosialin expression is strongly upregulated in the tumor stroma, scattered endosialin+ fibroblasts are detected in normal tissues (online supplemental figure 1), however, no visible differences in endosialin-staining were observed in bladder and skin tissues between E3K CAR and Mock-T cell treated tumor-bearing Cd248WT mice (figure 4H). This evidence concerns the gene CD248 and neoplasm.