Further, characterization of the E3K CAR-T cells that have homed to the tumor will be important to determining whether they would benefit from next generation engineering,50 such as ablating TGFBR2 to prevent T cell exhaustion in the transforming growth factor-β (TGF-β)-rich TME51 or co-expressing IL-7 and CCL19 to enhance infiltration and survival.52 Here, TGFB1 is linked to neoplasm.