CD248 and invasive breast carcinoma: Similarly, interrogation of gene expression profiling data of stroma microdissected from human malignant or normal breast,29 colon30 or ovary31 tissues demonstrated significantly upregulated CD248 expression in the tumor stroma (figure 1B) while immunohistochemical analysis of a human invasive breast cancer tissue microarray revealed pronounced endosialin staining on pericytes in 184 out of 219 (84%) and on CAFs in 147 (67%) of the cases, (figure 1C).