By contrast, when compared with the Mock-T cell-treated Cd248WT mice, tumors in E3K CAR-T-treated Cd248WT mice displayed a significant increase in tumor necrosis (figure 4E), likely due to depletion of endosialin+ cells and loss of endomucin+ endothelial cells in the tumor stroma (figure 4F), and significantly reduced metastatic burden (figure 4G). This evidence concerns the gene EMCN and neoplasm.