CASP9 and neoplasm: For example, in the recent GD2-CART01 trial, the CAR-T cells express an inducible caspase 9 suicide gene which was activated in one patient with successful CAR-T cell depletion.1 Alternatively, integration of an ON or OFF switch CAR design has been demonstrated in preclinical models to allow titratable remote control of CAR-T cell function, alleviating toxicities associated with excessive cytokine secretion or on-target off-tumor activity.56 57