Further, a trend towards reduced tumor growth (online supplemental figure 7D), a reduction in endosialin+ cells within the tumors (online supplemental figure 7E) and, a striking reduction in the number of metastatic lung deposits was observed in the E3K CAR-T cell treated cohort, with 70% of E3K CAR-T cell treated mice having no detectable lung disease (online supplemental figure 7F). This evidence concerns the gene CD248 and lung disorder.