Cd248WT mice treated with E3K CAR-T cells showed a significant decrease in primary tumor growth and tumor weight at necropsy in (figure 6D) and a significant depletion of endosialin+ cells, but not endomucin+ endothelial cells, within the tumor stroma (figure 6E) indicating that in the AT-3 tumors where the vessels are larger and more mature compared with the 4T1 tumors, depletion of endosialin+ pericytes is insufficient to disrupt the vascular architecture. Here, EMCN is linked to neoplasm.