ACKR3 and esophageal squamous cell carcinoma: Knockdown of CXCR7 led to a reduction in proliferation and chemoresistance induced by IL-6; furthermore, silencing CXCR7 led to a drastic reduction in gene expression profile related to stemness, chemoresistance, and EMT, as well as suppressing ESCC cell proliferation in angiogenesis assay and three-dimensional culture systems[138].