MCL1 and familial pancreatic carcinoma: Wei et al[55] stably expressed shRNAs targeting the MCL-1 gene in pancreatic cancer cell lines, namely SW1900, BxPC-3, and PANC-1, and showed that downregulation of MCL-1 caused apoptosis, inhibited cell growth, cell cycle arrest, and colony formation in pancreatic cell lines; additionally, MCL-1 knockdown led to an increased sensitivity to the standard of care drug gemcitabine in pancreatic cell lines.