RPA1 and hypopharynx cancer: Liu et al[48] established the FaDu-RR hypopharyngeal cancer cell line by repeatedly subjecting the FaDu cell line to ionizing radiation, with a cumulative dosage of 60 Gy; additionally, they carried out a microarray and bioinformatics study of FaDu-RR cells and discovered that four essential proteins in homologous recombination pathways, BRCA1, BRCA2, RPA1, and RAD51, express themselves at significantly higher levels in FaDu-RR cells than in the control cells; furthermore, silencing RPA1 reduced the radioresistance of FaDu-RR cells.