BAG1 and Familial prostate cancer: This is an important observation, as although one could postulate that BAG-1 function may be critical in the context of human disease complexity, which is very different to normal mouse prostate development and in vitro/vivo prostate cancer cell line models, or BAG-1 KO/knockdown may be incomplete, it also suggests that BAG-1 function may not be critical for prostate cancer cell survival and this requires careful consideration if targeting BAG-1 is to be pursued as a therapeutic target for this common disease.