BAG1 and Familial prostate cancer: A further consideration is that although BAG-1 mRNA associates with key signaling pathways implicated in the development and progression of prostate cancer in CRPC patient transcriptomes; this was not recapitulated in RNA-seq analyses of normal mouse prostates and LNCaP cells with BAG-1 KO/knockdown, and no significant phenotype was observed with BAG-1 KO/knockdown across multiple prostate cancer cell lines (3, 61–64).