In individuals with HIV-1–TB coinfection, both CD4 and CD8 T cells showed higher expression of IFN-inducible genes such as IFI27, IFI44, IFI44L, and ISG15 (Figure 6A, Supplementary Figure 5B), suggesting greater antiviral activity in these cells compared to those in TB patients. The gene discussed is CD4; the disease is tuberculosis.