CLOCK and cancer: EAA derived from the Horvath pan-tissue clock (also known as the Horvath1 clock), an estimator of chronological age across most tissues and life stages [37], has been associated with physical development [38], onset of puberty [39], and psychiatric problems in children and adolescents [38–40], as well as with cancer, physical function, cognition, and life expectancy in adults [33, 41].