Iron overload is common among NAFLD patients (Datz et al., 2017), and the excess iron along with inflammation can induce hepcidin in these patients (Vela, 2018; Zhou and Qiu, 2022; Senates et al., 2011; Mitsuyoshi et al., 2009). The gene discussed is HAMP; the disease is metabolic dysfunction-associated steatotic liver disease.