HBE1 and infection: In this study, among people who acquired HIV by either the blood route or by sexual contact, the combinations of HBsAg/anti-HBe and HBeAg/anti-HBs were detected, which could account for the transient coexisting phases of antigens and antibodies, the overlapping infection of different subtypes of HBV, or the deletion of genes in the S region or pre-S region of HBV.