Our team has investigated molecular and cellular factors that induce and propagate emergence of chemoresistance in patients with ovarian cancer,13,14,15,16 including tumor cell communication networks that bridge malignant cells distributed throughout heterogeneous stroma-rich tumors that present with higher TSP.17 These communication networks are induced by hypoxia18 and other characteristic properties of proliferating tumors19 and are just 1 example of factors underlying with association of TSP with ovarian cancer chemoresistance. This evidence concerns the gene THBS1 and ovarian cancer.