Alcohol consumption interacted with gene sets that share biological pathways with protein-coding genes (PRM1 [Ensembl ENSG00000175646], PRM2 [Ensembl ENSG00000122304], PRM3 [Ensembl ENSG00000178257], and TNP2 [Ensembl ENSG00000178279]) involved in chromosome condensation and male infertility activities (eFigure 6 in Supplement 1). This evidence concerns the gene TNP2 and male infertility.