In contrast to the acute post-injury period, during the subacute period, the bulk of the neurodegenerative disease associated protein variants had been cleared from the brain, except for two specific toxic protein variants, the C6T (Aβ) variant [48, 59] and the F9T (tau) variant [31, 60, 61], which accounted for all of the significant correlations between subacute behavioral deficits and protein variant levels. This evidence concerns the gene MAPT and neurodegenerative disease.