In contrast, subcutaneously transplanted tumor cells in mice fed with HFDs outcompete CD8+ T cells for lipids within the TME, resulting in reduced fatty acid uptake by intratumoral CD8+ T cells and impaired CD8+ T cell function (Ringel et al., 2020), suggesting context-dependent effects of extrinsic lipids on intratumoral CD8 T cell function under HFDs. The gene discussed is CD8A; the disease is neoplasm.