FOXO1 and metabolic dysfunction-associated steatohepatitis: Accordingly, in the context of nonalcoholic steatohepatitis (NASH), a systemic metabolic disease that causes liver damage, acetate promotes the auto-aggressive phenotype of CXCR6+ CD8+ T cells sensitized by IL-15 signaling and low FOXO1 expression (Dudek et al., 2021).