CD8A and breast cancer: Further, calorie restriction in combination with radiation or chemotherapy lowers intratumoral Treg cells and expands CD8+ T cells in tumor-bearing mice (Manukian et al., 2021; Pietrocola et al., 2016), and human patients with breast cancer undergoing a similar treatment have reduced immunosuppressive cytokine levels in the serum (Manukian et al., 2021).