When TRIM3 is overexpressed in these tumors, it exhibits a promising anticancer effect, and it is mainly not only through the regulation of the NF-κB signaling pathway, Notch signaling pathway, and P38 signaling pathway, but also through the regulation of cell cycle, regulation of tumor cell dryness, EMT, and other mechanisms to play a tumor inhibitory role, although the specific biological behaviors and underlying mechanisms may vary among different tumor types. This evidence concerns the gene NFKB1 and neoplasm.