There was a significant difference in pathological ENE between the two cohorts (p = 0.008), but no significant differences were found in CA199, CEA, tumor length, wall thickness, age, sex, location, cT stage, pathological LN, MRI-reported EMVI, LN-irregular border and/or adjacent fat invasion, LN-CSE, and LN-heterogeneous intensity between the two cohorts (all p > 0.05) (Table 1). This evidence concerns the gene CEACAM5 and neoplasm.