To identify a genetic signature of a link between necrosis and inflammation called “necroinflammation,” we selected the genes upregulated with S100A9 in GBM that were associated with inflammatory processes and at the same time were upregulated in the necrotic zone compared to the rest of the areas in the IvyGap dataset (Supplementary Figure 3F and G). The gene discussed is S100A9; the disease is glioblastoma.