Within the genes expressed in necrosis areas, we highlight S100A9 (Supplementary Figure 3A), a member of the S100 family which is involved in glioma progression, metastasis, invasion, and so on.27 S100A9 is also called a myeloid-related protein and as the name suggests these proteins are specifically highly expressed in myeloid cells, as we can observe in a single-cell RNA-seq analysis of human glioma samples28 (Supplementary Figure 3C and D). The gene discussed is S100A1; the disease is central nervous system cancer.