HMGB1 and neoplasm: Certain molecules, which have been dubbed DAMPs or alarmins, are thought to promote inflammation upon release from necrotic cells.36 Of interest, DAMPs that are enriched in glioma tissue are adenosine/adenosine triphosphate (ATP), hyaluronan (HA), high-mobility group box 1 (HMGB1), interleukin (IL)-1α, and S100 proteins.37 Our in silico analysis with the YvyGap dataset showed the upregulation of S100A in the necrotic zone compared to the rest of the tumor areas, confirming the expression linked to the necrotic processes of these genes in glioma.