S100A9 and neoplasm: Based on our stratification surprisingly the male patients who received BVZ therapy with a phenotype of high necrosis (Figure 6D and E) and inflammation linked to high infiltration of S100A9 positive myeloid cells (Figure 6F), obtained a survival benefit (Figure 6G), that is not shown by male patients without this tumor necroinflammation phenotype, nor by female patients.