ESR1 and glioblastoma: To our surprise, if we stratified only female patients with GBM into 2 groups based on high and low ESR1 expression values we did not observe any implication in survival (Supplementary Figure 2H), but if we stratified the male patients we observed that a higher transcription of this gene was associated with an increased in overall survival (Figure 1D and Supplementary Figure 2I), becoming survival rate in men with high transcription of ESR1 similar to female patients (Figure 1E and Supplementary Figure J).