Moreover, the expression of ESR1 correlated with overall survival in glioma (TCGA glioma diffuse cohort) (Figure 1B) and GBM TCGA cohort (Figure 1C), but with an inverse correlation in Astrocytoma IDHmut (Supplementary Figure 2C), showing the same affectation as when we sub-grouped the patients by sex. The gene discussed is ESR1; the disease is central nervous system cancer.