In cholelithiasis, compared with the non‐SAP group, the SAP group had significant differences in IL‐6 and IFN‐γ (p < .05), however, IL‐1β, IL‐5, IL‐8, IL‐10, IL‐17, TNF‐α did not show statistical differences between the two groups. This evidence concerns the gene IL6 and cholelithiasis.