Interestingly, the production of colony‐stimulating factor‐1 (CSF‐1), hepatocyte growth factor (HGF), and epidermal growth factor (EGF) by ovarian cancer cells, endothelial cells, and TAMs, respectively, and the formation of a paracrine loop was shown to be crucial for metastatic progression [175, 178, 180]. The gene discussed is EGF; the disease is ovarian cancer.