Two anti-CTLA-4 drugs have been studied in patients with melanoma: i) Ipilimumab, the first ICI evaluated and approved for the treatment of melanoma is a fully human immunoglobulin anti-CTLA-4 monoclonal antibody (20,21); ii) tremelimumab, a fully human immunoglobulin anti-CTLA-4 monoclonal antibody which is still under investigation (12). This evidence concerns the gene CTLA4 and melanoma.