Based on promising results from clinical trials, antibodies that inhibit PD-1 (such as pembrolizumab, nivolumab-IgG4 fully humanized and dostarlimab), as well as those that inhibit PD-L1 (such as avelumab, atezolizumab, and durvalumab) are being evaluated for use in melanoma cases and various other malignancies (NCT04020809, NCT04274816, NCT03313206, NCT03842943 and NCT05928962). This evidence concerns the gene CD274 and melanoma.