iii) A diagnosis of definite manganism requires that a clinically probable case has a) histopathological confirmation obtained from an autopsy (if available) or a cerebral biopsy (if available); and b) a normal Fluoro-Dopa or dopamine transporter (DAT) positron emission tomography (F-Dopa PET or DAT PET) scan (a normal scan would confirm manganism, but an abnormal scan would not exclude the disease). Here, SLC6A3 is linked to manganese poisoning.