NR3C2 and secondary hyperparathyroidism: PA may deteriorate bone health through (1) secondary hyperparathyroidism due to increased urinary calcium (33); (2) a direct effect on bone health through the distribution of mineralocorticoid receptors in human osteoclasts, osteoblasts, osteocytes, and parathyroid tissue (34, 35); and (3) reduced bone formation and increased apoptosis of osteoblasts and osteocytes caused by inflammation due to oxidative stress (36, 37).