Although the involvement of multifunctional T cells producing double and triple combinations of IL-2, TNF-α, and IFN-γ in the generation of a Th1 response has been widely established in the vaccination and cure of leishmaniasis (9–11, 59), this approach has not been similarly explored regarding the double- and triple-producers of Th2 cytokines. This evidence concerns the gene IFNG and leishmaniasis.