Adults are presenting with opportunistic Infections (OIs) experiences, baseline CD4 < 200 cells/μL counts, 1e, tenofovir disoproxil fumarate–lamivudine–efavirenz ART regimen, bedridden baseline functional status, World Health Organization (WHO) clinical stage II and III were notably associated with the incidence of ADRs development. The gene discussed is CD4; the disease is Opportunistic infection.