CCNE1 and neoplasm: Increased H3-pS10 expression was also observed in PKMYT1i-ATRi treated CCNE1AMP (KLE and FUOV1) cells but not in CCNE1GAIN (OVCAR8) or CCNE1LOW (WO-20) cells indicating a conserved mechanism-of-action in tumor-derived CCNE1-amplified models (Fig. 5E).