Among the biological pathways significantly enriched in AD-specific proteomic alterations, in the first group (G1) of proteins based on their pseudo-trajectories includes pathways of neurodegeneration (FDR = 1.6×10−05) and tau phosphorylation, and apoptosis, which is likely capturing neuronal death (Supplementary Table 7–10 and Extended Data Fig. 6–9). This evidence concerns the gene MAPT and Alzheimer disease.