Consistent with previous proteomic studies, some of the significantly up-regulated proteins included known AD biomarkers such as SMOC1 (FDR = 2.8×10−181), 14–3-3 protein YWHAG (P = 4.1×10−179), PPP3R1 (FDR = 1.8×10−146), and NRGN (FDR = 1.8×10−90). This evidence concerns the gene NRGN and Alzheimer disease.