Besides having these established AD biomarkers, this group also included NCK Adaptor Protein 2 (NCK2) and SHANK Associated RH Domain Interactor (SHARPIN) which are located on two known AD risk loci.34 Recent studies have revealed that SMOC1 protein in the brain colocalizes with Aβ plaques35 and its CSF levels increase almost 30 years before AD symptom onset.36 Here, SHARPIN is linked to Alzheimer disease.