For instance, proteins like SMOC1,18,19,22 YWHAG,18,19,22 ALDOA,18,19,22 ITGB2,16,18,19,22, SOD1,16,18,19,22 and NRGN18,19,22 showed significantly increased abundance in AD (A+T+), whereas, AHSG,18,19 CD74,18,19 and FLT318,22 showed reduced levels in the CSF of AD individuals in comparison to healthy controls (A−T−). The gene discussed is CD74; the disease is Alzheimer disease.