SNCA and Alzheimer disease: For example, the Apolipoprotein E (APOE) gene, which encodes a protein responsible for binding and transporting low-density lipids, significantly influences the risk of late-onset AD, the most prevalent form of dementia.5,6 Similarly, the Microtubule-associated protein tau (MAPT) is a recognized genetic mutation in FTD,7 and Synuclein Alpha (SNCA) is associated with PDD.8 While these studies have deepened our understanding of the genetic architecture of dementia, additional research is necessary to successfully model personal dementia genetic risk and understand the potential limitations.