APOE and Alzheimer disease: In the comparison of three representative models, namely 1) the APOE-e4 model; 2) the best-performing PRS model; and 3) the best-performing Elastic Net SNP model, our results mirrored those from the UCLA ATLAS sample, with the Elastic Net SNP model, which included gene-annotated SNPs from GWASs of AD and other dementia-related diseases, outperforming all other models in terms of the AUPRC and AUC in both the HLA and AA GIA samples (Table 3).